PRP is an autologous concentrate of platelets in a small volume of plasma with a platelet concentration greater than 1 million per milliliter of serum or greater than five times the baseline value of 150,000-350,000 / µl.
PRP is a source of cytokines, growth factors, and alpha-granules that promote tissue repair and wound healing.
PRP is used with an autologous process so it is NOT associated with allergic reactions or problems with self-antigens or hetero-antigens!
Local and systemic action of the PRP:
- Modulation of inflammation with anti-inflammatory action
stem cells recall with reduction of chondrocyte apoptosis and chondrogenesi
- Angiogenesis and synthesis of a new cellular matrix
- Induction of the release of further growth factors
- Analgesic and bacteriostatic action to slow down bacterial proliferation
CLINICAL APPLICATIONS OF PRP
Clinical indications in the orthopedic field with varying levels of evidence in different pathologies and districts for reparative treatments of:
reconstruction of the anterior cruciate ligament
- Rotator cuff reconstruction
- Tendinopathies (patellar, epicondylitis, Achilles tendon)
- Focal cartilage lesions
- Degenerative meniscal tear
- Plantar fasciitis
- Degenerative disc disease
Clinical indications also in the field of dentistry, dermatology, aesthetic medicine and plastic surgery
- Kim AD, et al. 2021 Platelet-Rich Plasma Injection in Patients with Atrophic Rhinitis. ORL J Otorhinolaryngol Relat Spec. 2021 Feb 9; 1-8.
- Bove A, et al. Platelet-rich plasma. Evidence, limits and future prospects 2019. Updates Lo Scalpello (2019) 33: 220-225.
- Yang et al. Medicine (2017) 96:44 (e8475).
- Hamid et al. American Journal of Sport Medicine published online July 2014.
- Akeda et al. Journal of Pain Research (2019): 12 753-767 10.